[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling
نویسندگان
چکیده
منابع مشابه
Radiosynthesis of no-carrier-added meta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma
Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess the diagnostic accuracy of [124I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [124I]sodium iodide and meta-trimethylsilylbenzylgua...
متن کاملSynthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added (18)F-Labelling Methods.
Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders. Selective inhibitors of the subtypes iNOS (inducible) or nNOS (neuronal) are of great interest for decoding neurodestructive key factors, and (18)F-labelled analogues would allow investigating the NOS-function by molecul...
متن کامل3137 104 Automated radiosynthesis of no - carrier - added 4 - [ 18 F ] fl uoroiodobenzene : a versatile building block in 18 F radiochemistry
4-[F]Fluoroiodobenzene ([F]FIB) is a versatile building block in F radiochemistry used in various transition metalmediated C–C and C–N cross-coupling reactions and [F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [F]FIB. However, to date, no automated synthesis of [F]FIB has been reported to allow access to larger amounts of [F]FIB in high radioc...
متن کاملTargetry for cyclotron production of no-carrier-added cadmium-109 from natAg(p,n)109Cd reaction
Background: Solid targets that consist of powder and electrodeposited targets are used commonly to produce radionuclides by accelerators. Since silver is easily electrodeposited in cyanide baths and has a very excellent thermal conductivity, the electrodeposited target is preferable to produce 109Cd. To avoid cracking or peeling of the target during bombardment, it should have a level surface a...
متن کاملProduction of no-carrier-added Ho-166 for targeted therapy purposes
Introduction:Holmium-166 radionuclide is one of the most effective radionuclides used for targeted therapy with theranostic properties. One method to produce this radioisotope is via the decay of its parent (indirect method). In this study applicability of extraction chromatography (EXC) for separation of no carrier added 166Ho from neutron-irradiated natura...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Communications
سال: 2018
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c8cc00526e